Publication

Molecular Genetics of Thalassemia: With a Glance at the Puzzle of Hemoglobin Switching and New Prospects in Therapy

Author(s)

Maryam Neishabury, PhD

Year

2014

Language

Persian

Scopus Subject Area

Hematology, Genetics and Molecular Biology, Biomedical Research

Citation Info

Neishabury M.Molecular Genetics of Thalassemia: With a Glance at the Puzzle of Hemoglobin Switching and New Prospects in Therapy. Tehran: University of Social Welfare and Rehabilitation Sciences (USWR Press); 2014. ISBN: 978‑600‑6442‑20‑4.

 

EndNote

summary

This book provides a comprehensive overview of the molecular genetics of thalassemia, with a particular focus on the mechanisms of hemoglobin switching. It explains how γ globin genes are actively expressed during fetal development and later silenced in adulthood, and discusses how reactivating these genes may alleviate clinical symptoms in β thalassemia. The text reviews global epidemiology, genetic classifications, regulatory elements of the β globin locus, transcriptional control, modifying genetic factors, and emerging therapeutic strategies—including pharmacologic agents, stem cell approaches, and gene therapy. It serves as a scientific guide for researchers and clinicians working in molecular hematology and thalassemia management.